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TRAF2 Polyclonal Antibody (CAB23680)

SKU:
CAB23680
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
WB
€139 - €529
Frequently bought together:

Description

TRAF2 Polyclonal Antibody (CAB23680)

The TRAF2 Polyclonal Antibody (CAB23680) is a valuable tool for researchers studying tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2), a key signal transducer in the TNF receptor superfamily. This antibody, produced in rabbits, is highly specific to TRAF2 and has been validated for use in Western blot applications. Its ability to target TRAF2 allows for the detection and analysis of this important protein in various cell types, making it a versatile tool for research in oncology, inflammation, and immune signaling pathways.

TRAF2 is known for its role in multiple cellular processes, including cell survival, apoptosis, and inflammation. Dysregulation of TRAF2 has been implicated in various diseases, such as cancer, autoimmune disorders, and inflammatory conditions. By targeting TRAF2 with this polyclonal antibody, researchers can gain insights into the molecular mechanisms underlying these diseases and potentially develop new therapeutic strategies for targeting TRAF2 in clinical settings.

Product Name:TRAF2 Polyclonal Antibody
Product Code:CAB23680
Reactivity:Human, Mouse, Rat
Applications:Western blotting
Host Species:Rabbit
Purification Method:Affinity purification
Isotype:IgG
Reactivity:Human, Mouse, Rat
Tested Applications:WB, ELISA
Key Applications:Western blotting
Recommended Dilution:WB 1:100-1:500
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3.
Positive Samples:HeLa, 293T
Cellular Location:Cytoplasm

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.

Immunogen:Recombinant protein of human TRAF2.
Sequence:DGCGK KKIPR EKFQD HVKTC GKCRV PCRFH AIGCL ETVEG EKQQE HEVQW LREHL AMLLS SVLEA KPLLG DQSHA GSELL QRCES LEKKT ATFEN IVCVL NREVE RVAMT AEACS RQHRL DQDKI EALSS KVQQL ERSIG LKDLA MADLE QKVLE MEAST Y
Synonyms:TRAP, TRAP3, RNF117, MGC:45012
Calculated MW:56kDa
Observed MW:56kDa

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