The TRAF2 Polyclonal Antibody (CAB21636) is a valuable tool for researchers studying TRAF2, an important protein involved in cell signaling pathways and immune responses. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to TRAF2, this antibody enables the detection and analysis of the protein in various cell types, making it an ideal choice for research in immunology, oncology, and inflammatory diseases.
TRAF2 is a key player in the activation of NF-kB signaling pathways and the regulation of immune and inflammatory responses. Dysregulation of TRAF2 has been implicated in various diseases, including cancer, autoimmune disorders, and inflammatory conditions. By studying TRAF2 using this polyclonal antibody, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.
Product Name:
TRAF2 Polyclonal Antibody
SKU:
CAB21636
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 190-350 of human TRAF2 (NP_066961.2).
The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.
Purification Method:
Affinity purification
Gene ID:
7186
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse thymus, using TRAF2 Rabbit pAb (CAB21636) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 60s.
