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TP53INP2 Antibody (PACO46778)

SKU:
PACO46778
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IF
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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TP53INP2 Antibody (PACO46778)

The TP53INP2 Polyclonal Antibody (PAC04678) is a valuable tool for researchers studying TP53INP2, a protein involved in tumor suppression and cell apoptosis. This antibody, raised in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the TP53INP2 protein, this antibody enables efficient detection and analysis in a variety of cell types, making it ideal for investigations in cancer biology and cell signaling pathways.TP53INP2, also known as tumor protein p53 inducible nuclear protein 2, is a key player in the regulation of p53-dependent cell death pathways and has been implicated in various cellular processes including DNA damage response and autophagy.

Its role in promoting tumor suppression makes it a promising target for cancer research and drug development. By understanding the function and regulation of TP53INP2, researchers can uncover novel therapeutic strategies for combating cancer and other related diseases.

Antibody Name:TP53INP2 Antibody (PACO46778)
Antibody SKU:PACO46778
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, IF
Recommended Dilutions:ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:Human
Immunogen:Recombinant Human Tumor protein p53-inducible nuclear protein 2 protein (100-220AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageImmunofluorescent analysis of MCF-7 cells using PACO46778 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.
Synonyms:Tumor protein p53-inducible nuclear protein 2 (Diabetes and obesity-regulated gene) (p53-inducible protein U) (PIG-U), TP53INP2, C20orf110 DOR PINH
UniProt Protein Function:TP53INP2: Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.Chromosomal Location of Human Ortholog: 20q11.22Cellular Component: autophagic vacuole; cytoplasmic vesicle; cytosol; nucleus; PML bodyMolecular Function: protein binding; ubiquitin bindingBiological Process: autophagic vacuole formation; osteoblast differentiation; positive regulation of autophagy; positive regulation of transcription, DNA-dependent; tissue homeostasis; transcription, DNA-dependent; ubiquitin-dependent protein catabolic process
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q8IXH6
NCBI GenInfo Identifier:32699566
NCBI Gene ID:58476
NCBI Accession:Q8IXH6.2
UniProt Secondary Accession:Q8IXH6,Q5JX64, Q8IYL5, Q9NU00, A8K8S8, E1P5P6
UniProt Related Accession:Q8IXH6
Molecular Weight:23,980 Da
NCBI Full Name:Tumor protein p53-inducible nuclear protein 2
NCBI Synonym Full Names:tumor protein p53 inducible nuclear protein 2
NCBI Official Symbol:TP53INP2  
NCBI Official Synonym Symbols:DOR; PINH; C20orf110; dJ1181N3.1  
NCBI Protein Information:tumor protein p53-inducible nuclear protein 2
UniProt Protein Name:Tumor protein p53-inducible nuclear protein 2
UniProt Synonym Protein Names:Diabetes and obesity-regulated gene; p53-inducible protein U; PIG-U
Protein Family:Tumor protein p53-inducible nuclear protein
UniProt Gene Name:TP53INP2  
UniProt Entry Name:T53I2_HUMAN
Antibodies
TP53INP2 Antibody (PACO04856)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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