The TMC1 Polyclonal Antibody (CAB8595) is designed for research involving TMC1, a transmembrane channel protein involved in hearing and deafness. This antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in Western blot applications. TMC1 is crucial for the proper function of hair cells in the inner ear, playing a critical role in auditory transduction. Mutations in the TMC1 gene have been linked to various forms of hereditary hearing loss, making it a valuable target for research in the field of auditory biology and deafness.
By using the TMC1 Polyclonal Antibody, researchers can detect and analyze the expression of TMC1 protein in different cell types, contributing to a better understanding of its function in hearing and deafness. This antibody is a valuable tool for studies aiming to uncover the mechanisms underlying hearing loss and develop potential therapies for hearing-related disorders.
Product Name:
TMC1 Rabbit Polyclonal Antibody
SKU:
CAB8595
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 600-700 of human TMC1 (NP_619636.2).
This gene is considered a member of a gene family predicted to encode transmembrane proteins. The specific function of this gene is unknown; however, it is known to be required for normal function of cochlear hair cells. Mutations in this gene have been associated with progressive postlingual hearing loss and profound prelingual deafness.
Purification Method:
Affinity purification
Gene ID:
117531
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse eye, using TMC1 Rabbit pAb (CAB8595) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 90s.
