The role of key Interleukins

Interleukin signaling is involved in a number of biological processes, including cell growth and differentiation, inflammation and immunity. Interleukins are glycoproteins which act on hematopoietic cells to regulate immune responses or target cells for destruction by the immune system. Interleukins mediate communication between cells through a complex network of receptors. Interleukin receptors are members of a large family of cell surface molecules called cytokine receptors. Interleukins bind to the receptor and cause it to dimerize with another interleukin receptor, which in turn stimulates activity within the target cells. Interleukins play a major role in host defense against infection, inflammation and growth.

Interleukin signaling pathways are involved in immune responses associated with tuberculosis, leprosy and AIDS. Interleukins are also associated with autoimmune disorders such as arthritis, inflammatory bowel disease or psoriasis. Interleukin 1 receptor blockade has been proposed as a treatment for autoimmune diseases such as rheumatoid arthritis and psoriasis. Interleukin 2 is important in the mediation of cell-mediated immune responses, particularly cytotoxic T lymphocyte (CTL) responses against virally infected cells and tumor cells. Interleukin 7 (IL-7) and Interleukin 15 (IL-15) are involved in the growth and differentiation of long-term memory T cells. Interleukin signaling pathways play a central role in several stages of cancer progression.

Interleukins such as Interleukin 1, Interleukin 6, Interleukin 8, Interleukin 18 and Interleukin 23 are involved in tumor development [5]. Interleukin 6 (IL-6) is a multifunctional cytokine known to be associated with cancer. Interleukins are important players in angiogenesis, the formation of blood vessels that supply nutrients and oxygen to tumor cells.

Interleukin 17 is a cytokine involved in human autoimmune diseases such as rheumatoid arthritis and psoriasis. Interleukin 12 (IL-12) is a proinflammatory cytokine associated with Th1 cell development, Interleukin 23 (IL-23) is a proinflammatory cytokine associated with Th17 cell development, Interleukin 15 (IL-15) is a cytokine involved in the proliferation and survival of some immune cells, Interleukin 18 (IL-18) is an immunoregulatory cytokine that regulates natural killer T function. Interleukins are important players in the immune system and Interleukin signaling pathways play a key role in inflammatory processes. Interleukin receptors are members of a large family of cell surface molecules called cytokine receptors. Interleukins bind to their receptors and cause them to dimerize with another Interleukin receptor, which in turn stimulates activity within the target cells. Interleukin receptor activation of Interleukin signaling pathways is involved in immune responses associated with tuberculosis, leprosy and AIDS.

Interleukin 1 receptor blockade has been proposed as a treatment for autoimmune diseases such as rheumatoid arthritis and psoriasis. Interleukins also influence Interleukin signaling pathways linked to angiogenesis, the formation of blood vessels that supply nutrients and oxygen to tumor cells. Interleukin 17 is a cytokine involved in human autoimmune diseases such as rheumatoid arthritis and psoriasis. Interleukins are important players in the immune system and Interleukin signaling pathways play a key role in inflammatory processes. Interleukin receptors are members of a large family of cell surface molecules called cytokine receptors. Interleukins bind to their receptors and cause them to dimerize with another Interleukin receptor, which in turn stimulates activity within the target cells.