The SPINK1 Polyclonal Antibody (CAB1096) is a valuable tool for researchers studying SPINK1, a serine protease inhibitor involved in various physiological processes, including pancreatic function and inflammation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the SPINK1 protein, this antibody enables precise detection and analysis in diverse cell types, making it ideal for investigations in fields such as gastroenterology and pancreatic cancer research.
SPINK1, also known as pancreatic secretory trypsin inhibitor, plays a crucial role in maintaining pancreatic homeostasis by regulating enzymatic activities and protecting against autodigestion. Dysregulation of SPINK1 is associated with pancreatic diseases, such as pancreatitis and pancreatic cancer, highlighting its potential as a therapeutic target for these conditions. Understanding the functions of SPINK1 is essential for developing treatments that modulate its activity and address the underlying mechanisms of pancreatic disorders.
Product Name:
SPINK1 Rabbit Polyclonal Antibody
SKU:
CAB1096
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 24-79 of human SPINK1 (NP_003113.2).
The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis.
Purification Method:
Affinity purification
Gene ID:
6690
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse intestine, using SPINK1 antibody (CAB1096) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
