The SOD2 Polyclonal Antibody is a valuable tool for researchers studying the SOD2 protein, which plays a crucial role in antioxidant defense. This antibody, produced in rabbits, has a high reactivity with human samples and is validated for use in Western blot applications. By binding to the SOD2 protein, this antibody allows for the detection and analysis of SOD2 in a variety of cell types, making it an essential component in studies related to oxidative stress, cancer, and other diseases.SOD2, also known as manganese superoxide dismutase, is an essential enzyme that helps to protect cells from damage caused by reactive oxygen species.
Dysregulation of SOD2 has been linked to various pathological conditions, including cancer, neurodegenerative diseases, and cardiovascular disorders. Therefore, investigating the function and regulation of SOD2 is critical for developing novel therapeutic approaches targeting oxidative stress-related diseases. Overall, the SOD2 Polyclonal Antibody is a reliable tool for researchers aiming to explore the role of SOD2 in health and disease, providing valuable insights into the mechanisms underlying oxidative stress and potential therapeutic targets.
Product Name:
SOD2 Polyclonal Antibody
SKU:
CAB21805
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 25-222 of human SOD2 (NP_000627.2).
This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1.
Purification Method:
Affinity purification
Gene ID:
6648
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis lysates from HepG2, using SOD2 Rabbit pAb (CAB21805) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
