| UniProt Protein Function: | Mitochondrial sodium/calcium antiporter that mediates sodium-dependent calcium efflux from mitochondrion, by mediating the exchange of 3 sodium ions per 1 calcium ion (PubMed:20018762, PubMed:22829870, PubMed:23056385, PubMed:24898248, PubMed:28219928). Plays a central role in mitochondrial calcium homeostasis by mediating mitochondrial calcium extrusion: calcium efflux is essential for mitochondrial function and cell survival, notably in cardiomyocytes (). Regulates rates of glucose-dependent insulin secretion in pancreatic beta-cells during the first phase of insulin secretion: acts by mediating efflux of calcium from mitochondrion, thereby affecting cytoplasmic calcium responses (PubMed:23056385). Required for store-operated Ca2+ entry (SOCE) and Ca2+ release-activated Ca2+ (CRAC) channel regulation: sodium transport by SLC8B1 leads to promote calcium-shuttling that modulates mitochondrial redox status, thereby regulating SOCE activity (PubMed:28219928). Involved in B-lymphocyte chemotaxis (). Able to transport Ca2+ in exchange of either Li+ or Na+, explaining how Li+ catalyzes Ca2+ exchange (PubMed:15060069). In contrast to other members of the family its function is independent of K+ (PubMed:15060069). |
| UniProt Protein Details: | |
| NCBI Summary: | SLC24A6 belongs to a family of potassium-dependent sodium/calcium exchangers that maintain cellular calcium homeostasis through the electrogenic countertransport of 4 sodium ions for 1 calcium ion and 1 potassium ion (Cai and Lytton, 2004 [PubMed 14625281]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q6J4K2 |
| NCBI GenInfo Identifier: | 1060099165 |
| NCBI Gene ID: | 80024 |
| NCBI Accession: | NP_001317395.1 |
| UniProt Secondary Accession: | Q6J4K2,Q4KMS9, Q6J4K1, Q9H6I8, A6NP50 |
| UniProt Related Accession: | Q6J4K2 |
| Molecular Weight: | 58,087 Da |
| NCBI Full Name: | mitochondrial sodium/calcium exchanger protein isoform 2 |
| NCBI Synonym Full Names: | solute carrier family 8 member B1 |
| NCBI Official Symbol: | SLC8B1Â Â |
| NCBI Official Synonym Symbols: | NCLX; NCKX6; SLC24A6Â Â |
| NCBI Protein Information: | mitochondrial sodium/calcium exchanger protein |
| UniProt Protein Name: | Mitochondrial sodium/calcium exchanger protein |
| UniProt Synonym Protein Names: | Na(+)/K(+)/Ca(2+)-exchange protein 6 |
| Protein Family: | |
| UniProt Gene Name: | SLC8B1Â Â |
| UniProt Entry Name: | |
