The SLC5A5 Polyclonal Antibody (CAB9605) is a valuable tool for researchers studying the sodium/iodide symporter (NIS) protein, encoded by the SLC5A5 gene. This antibody, produced in rabbits, has been validated for its high reactivity with human samples and is suitable for use in Western blot applications. By binding to the NIS protein, this antibody enables the detection and analysis of NIS in various cell types and tissues.The sodium/iodide symporter is essential for the uptake of iodide in thyroid follicular cells, playing a crucial role in thyroid hormone synthesis.
Dysregulation of NIS function has been implicated in thyroid disorders, including hypothyroidism and thyroid cancer. Understanding the expression and activity of NIS is important for research in thyroid biology, radioiodine therapy, and diagnostic imaging techniques.Overall, the SLC5A5 Polyclonal Antibody is a valuable tool for investigating the role of the sodium/iodide symporter in thyroid function and related disorders. Its high reactivity and specificity make it an ideal choice for studies in endocrinology and cancer research.
Product Name:
SLC5A5 Rabbit Polyclonal Antibody
SKU:
CAB9605
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 544-643 of human SLC5A5 (NP_000444.1).
This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.
Purification Method:
Affinity purification
Gene ID:
6528
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SLC5A5 pAb (CAB9605) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
