The SLC1A3 Polyclonal Antibody (CAB15722) is a valuable tool for researchers studying SLC1A3, a protein involved in the regulation of glutamate transport and neurotransmitter homeostasis. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.SLC1A3, also known as excitatory amino acid transporter 1 (EAAT1), plays a crucial role in the uptake of glutamate from the synaptic cleft, maintaining proper neurotransmission and preventing excitotoxicity. Dysregulation of SLC1A3 has been implicated in various neurological disorders, including epilepsy, Alzheimer's disease, and schizophrenia.
By targeting the SLC1A3 protein, researchers can gain valuable insights into the mechanisms underlying these disorders and potentially identify new therapeutic targets for drug development. The SLC1A3 Polyclonal Antibody is an essential tool for investigating the function and expression of SLC1A3 in different cell types, advancing our understanding of glutamate transport and its role in neurological health and disease.
Product Name:
EAAT1/SLC1A3 Rabbit Polyclonal Antibody
SKU:
CAB15722
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 453-542 of human EAAT1/EAAT1/SLC1A3 (NP_004163.3).
This gene encodes a member of a member of a high affinity glutamate transporter family. This gene functions in the termination of excitatory neurotransmission in central nervous system. Mutations are associated with episodic ataxia, Type 6. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
6507
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using EAAT1/SLC1A3 Rabbit pAb (CAB15722) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
