The SLC16A8 Antibody (PAC020475) is a valuable tool for researchers studying SLC16A8, a member of the SLC16 family of transporters involved in monocarboxylate transport. This polyclonal antibody, produced in hosts such as rabbits, exhibits high specificity for human samples and has been validated for use in Western blot experiments. By specifically binding to the SLC16A8 protein, this antibody enables precise detection and analysis in a variety of cell types, making it an essential tool for researchers in the fields of metabolism and cancer research. SLC16A8, also known as MCT3, plays a crucial role in monocarboxylate transport across cell membranes, contributing to various physiological processes such as energy metabolism and lactate transport.
Dysregulation of SLC16A8 has been implicated in conditions such as metabolic disorders, cancer, and neurological diseases. Therefore, investigating the function of SLC16A8 is essential for understanding its role in these diseases and developing potential therapeutic interventions. The SLC16A8 Antibody is a key component in these research efforts, providing researchers with a reliable means to study the expression and function of SLC16A8 in disease models and clinical samples.
Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane: Human fetal brain tissue, Primary antibody: PACO20475(SLC16A8 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20475(SLC16A8 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes. Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acid, derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate.
Synonyms:
solute carrier family 16 (monocarboxylate transporter), member 8
UniProt Protein Function:
SLC16A8: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.
Biological Process: lactate transport; leukocyte migration; pyruvate metabolic process
NCBI Summary:
SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]
