The SLC16A11 Polyclonal Antibody (PAC06105) is a valuable tool for researchers studying the SLC16A11 protein, a member of the SLC16A transporter family involved in glucose and lipid metabolism. This antibody, generated in rabbits, shows strong reactivity with human samples and is optimized for Western blot applications. By specifically binding to SLC16A11, researchers can detect and analyze this transporter protein in a variety of cell types, making it ideal for investigations in metabolism, diabetes, and related diseases.
SLC16A11 is a key player in glucose and lipid homeostasis, playing a role in regulating metabolic processes and insulin sensitivity. Dysfunction of SLC16A11 has been linked to metabolic disorders such as diabetes and obesity, making it a promising target for therapeutic development. Understanding the function and regulation of SLC16A11 is essential for unveiling the mechanisms underlying metabolic diseases and developing targeted interventions to improve metabolic health.
Western Blot. Positive WB detected in: A549 whole cell lysate, Hela whole cell lysate. All lanes: SLC16A11 antibody at 3.8µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 48 kDa. Observed band size: 48 kDa.
Immunofluorescence staining of A549 cells with PACO61105 at 1:150, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Proton-linked monocarboxylate transporter. May catalyze the transport of monocarboxylates across the plasma membrane (Probable). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids.
Synonyms:
Monocarboxylate transporter 11 (MCT 11) (Solute carrier family 16 member 11), SLC16A11, MCT11
UniProt Protein Function:
SLC16A11: Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.Protein type: Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass; TransporterChromosomal Location of Human Ortholog: 17p13.1Cellular Component: endoplasmic reticulum membrane; integral to plasma membraneMolecular Function: lactate transmembrane transporter activityBiological Process: lipid metabolic process
