The Siglec14 Monoclonal Antibody (PAC020464) is a valuable tool for researchers studying Siglec14, a cell surface protein involved in immune regulation and inflammation. This monoclonal antibody, generated in mice, specifically targets Siglec14 protein in human samples and is suitable for use in various applications, including Western blotting and immunohistochemistry.Siglec14 is a member of the Siglec family of proteins, which play important roles in immune cell signaling and regulation. It has been implicated in modulating immune responses and inflammatory processes, making it a promising target for research in immunology and disease pathogenesis. By utilizing the Siglec14 Monoclonal Antibody, researchers can detect and analyze Siglec14 expression in different cell types, providing valuable insights into its function and potential therapeutic implications.
Research on Siglec14 is particularly relevant in the fields of cancer immunology, autoimmune diseases, and inflammatory conditions, as dysregulation of immune checkpoints like Siglec14 can contribute to disease progression. By understanding the mechanisms by which Siglec14 influences immune responses, researchers can uncover new therapeutic strategies for targeting immune checkpoints and modulating immune function in various disease settings.
Antibody Name:
SIGLEC14 Antibody (PACO20464)
Antibody SKU:
PACO20464
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human SIGLEC14
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20464(SIGLEC14 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO20464(SIGLEC14 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Putative adhesion molecule. Sialic acid, binding paired receptor which may activate associated receptors. Interacts with TYROBP. Mainly expressed in hematopoietic tissues including bone marrow, spleen and fetal liver. Siglec-14 is predominantly expressed in hematopoietic tissues but is also found in lung and testis.
Synonyms:
sialic acid, binding Ig-like lectin 14
UniProt Protein Function:
SIGLEC14: Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Interacts with TYROBPChromosomal Location of Human Ortholog: 19q13.4Cellular Component: plasma membraneBiological Process: innate immune response
