The Siglec14 Monoclonal Antibody (PAC020463) is a valuable tool for researchers studying Siglec14, a member of the sialic acid-binding Ig-like lectin (Siglec) family involved in immune regulation. This antibody, produced in mice, exhibits high specificity and sensitivity for detecting Siglec14 in human samples and is suitable for use in applications such as Western blotting.Siglec14 is known to modulate immune responses and is implicated in various immune-related processes, including the regulation of inflammatory signaling pathways.
Its role in the immune system makes it a promising target for investigating diseases such as cancer, autoimmune disorders, and infectious diseases. By using the Siglec14 Monoclonal Antibody, researchers can explore the function of Siglec14 in different cell types and gain insights into its potential therapeutic implications in immunology and disease mechanisms.
Antibody Name:
SIGLEC14 Antibody (PACO20463)
Antibody SKU:
PACO20463
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:25-1:100
Species Reactivity:
Human
Immunogen:
Synthetic peptide of human SIGLEC14
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20463(SIGLEC14 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Putative adhesion molecule. Sialic acid, binding paired receptor which may activate associated receptors. Interacts with TYROBP. Mainly expressed in hematopoietic tissues including bone marrow, spleen and fetal liver. Siglec-14 is predominantly expressed in hematopoietic tissues but is also found in lung and testis.
Synonyms:
sialic acid, binding Ig-like lectin 14
UniProt Protein Function:
SIGLEC14: Putative adhesion molecule. Sialic acid-binding paired receptor which may activate associated receptors. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. Interacts with TYROBPChromosomal Location of Human Ortholog: 19q13.4Cellular Component: plasma membraneBiological Process: innate immune response
