The Siglec1 Polyclonal Antibody (CAB22677) is a powerful tool for researchers studying Siglec1, a protein involved in immune regulation and cell signaling. This antibody, generated in rabbits, has a high affinity for Siglec1 and is validated for use in various applications such as Western blotting. By specifically binding to Siglec1, researchers can accurately detect and analyze this important protein in a range of cell types.Siglec1, also known as CD169, is a sialic acid binding lectin that plays a crucial role in immune response modulation and host-pathogen interactions. Its expression is often associated with antigen-presenting cells and has been implicated in various disease processes, including viral infections and inflammatory disorders.
By studying the function of Siglec1, researchers can gain valuable insights into immune system regulation and potential therapeutic targets for diseases.Overall, the Siglec1 Polyclonal Antibody is an essential tool for researchers investigating the role of Siglec1 in immunology, infectious diseases, and autoimmune disorders. Its high specificity and sensitivity make it a reliable choice for experiments aiming to elucidate the function of this important protein in cellular pathways and disease mechanisms.
Product Name:
Siglec1 Polyclonal Antibody
SKU:
CAB22677
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-138 of mouse Siglec1(NP_035556.3).
early endosome, extracellular region, late endosome, plasma membrane
Calculated MW:
183kDa
Observed MW:
200kDa
Predicted to enable virion binding activity. Acts upstream of or within positive regulation of T cell apoptotic process and positive regulation of extrinsic apoptotic signaling pathway. Predicted to be located in extracellular region and membrane. Predicted to be integral component of membrane. Predicted to be active in early endosome; late endosome; and plasma membrane. Is expressed in immune system; reproductive system; and skin. Orthologous to human SIGLEC1 (sialic acid binding Ig like lectin 1).
Purification Method:
Affinity purification
Gene ID:
20612
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from Rat spleen using Siglec1 Rabbit pAb(CAB22677) at 1:700 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25 μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
