SHANK2 Rabbit Polyclonal Antibody (CAB18423)
- SKU:
- CAB18423
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | SHANK2 Rabbit Polyclonal Antibody |
SKU: | CAB18423 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 500-600 of human SHANK2 (NP_036441.2). |
Sequence: | PFAL GANK DSLS AFEY PGPK RKLY SAVP GRLF VAVK PYQP QVDG EIPL HRGD RVKV LSIG EGGF WEGS ARGH IGWF PAEC VEEV QCKP RDSQ AETR ADRS K |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | SHANK; AUTS17; CORTBP1; CTTNBP1; ProSAP1; SPANK-3; SHANK2 |
Positive Sample: | Mouse liver,Rat liver |
Cellular Localization: | apical plasma membrane, ciliary membrane, cytosol, dendritic spine, glutamatergic synapse, growth cone, hippocampal mossy fiber to CA3 synapse, neuron projection, plasma membrane, postsynaptic density, presynaptic active zone |
Calculated MW: | 201kDa |
Observed MW: | 159kDa |
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 22941 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |