The Epsilon Sarcoglycan Polyclonal Antibody (CAB5330) is a valuable tool for researchers studying the epsilon sarcoglycan protein, a key component of the dystrophin-glycoprotein complex that plays a crucial role in maintaining muscle cell structure and function. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.By targeting the epsilon sarcoglycan protein, this antibody allows for the detection and analysis of this important molecule in various cell types, making it ideal for studies focusing on muscular dystrophy, muscle regeneration, and neuromuscular disorders.
Understanding the role of epsilon sarcoglycan in muscle physiology is essential for developing therapeutic interventions aimed at treating conditions associated with dysfunction of the dystrophin-glycoprotein complex.Overall, the Epsilon Sarcoglycan Polyclonal Antibody (CAB5330) is a reliable tool for researchers looking to explore the function and significance of epsilon sarcoglycan in both normal and pathological conditions, ultimately contributing to advancements in the field of muscle biology and regenerative medicine.
Product Name:
SGCE Rabbit Polyclonal Antibody
SKU:
CAB5330
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-317 of human SGCE (NP_003910.1).
This gene encodes the epsilon member of the sarcoglycan family. Sarcoglycans are transmembrane proteins that are components of the dystrophin-glycoprotein complex, which link the actin cytoskeleton to the extracellular matrix. Unlike other family members which are predominantly expressed in striated muscle, the epsilon sarcoglycan is more broadly expressed. Mutations in this gene are associated with myoclonus-dystonia syndrome. This gene is imprinted, with preferential expression from the paternal allele. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A pseudogene associated with this gene is located on chromosome 2.
Purification Method:
Affinity purification
Gene ID:
8910
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SGCE antibody (CAB5330) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
