The SFTPA1 Polyclonal Antibody (PAC064511) is a valuable tool for researchers studying the protein SFTPA1, which is involved in pulmonary surfactant production and innate immune defense in the lungs. This antibody, produced in rabbits, has been validated for use in Western blot and immunohistochemistry applications, allowing for the detection and analysis of SFTPA1 in various tissues and cell types.SFTPA1, also known as surfactant protein A1, plays a crucial role in maintaining lung function and protecting against infections in the respiratory tract.
Its importance in pulmonary immunity makes it a promising target for investigations into lung diseases such as asthma, pneumonia, and acute respiratory distress syndrome. By studying the function and expression of SFTPA1, researchers can gain insights into respiratory conditions and potentially develop novel therapeutic approaches for treating these diseases.
Western Blot. Positive WB detected in: RAW264.7 whole cell lysate. All lanes: Sftpa1 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 27 kDa. Observed band size: 35 kDa.
Background:
In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-Liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.
Synonyms:
Pulmonary surfactant-associated protein A (PSAP) (PSP-A) (SP-A), Sftpa1, Sftp-1 Sftp1 Sftpa
UniProt Protein Function:
In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages.
NCBI Summary:
binds LPS and modifies LPS-induced immune cell activation in the lung [RGD, Feb 2006]
