SCRIB Rabbit Polyclonal Antibody (CAB17450)
- SKU:
- CAB17450
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
Product Name: | SCRIB Rabbit Polyclonal Antibody |
SKU: | CAB17450 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1100-1400 of human SCRIB (NP_874365.3). |
Sequence: | ELCI QKAP GERL GISI RGGA RGHA GNPR DPTD EGIF ISKV SPTG AAGR DGRL RVGL RLLE VNQQ SLLG LTHG EAVQ LLRS VGDT LTVL VCDG FEAS TDAA LEVS PGVI ANPF AAGI GHRN SLES ISSI DREL SPEG PGKE KELP GQTL HWGP EATE AAGR GLQP LKLD YRAL AAVP SAGS VQRV PSGA AGGK MAES PCSP SGQQ PPSP PSPD ELPA NVKQ AYRA FAAV PTSH PPED APAQ PPTP GPAA SPEQ LSFR ERQK YFEL EVRV PQAE GPPK RVSL VGAD DLRK MQEE EARK LQQK R |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | CRIB1; SCRB1; SCRIB1; Vartul; oSCRIB; SCRIB |
Positive Sample: | MCF7 |
Cellular Localization: | basolateral plasma membrane, extracellular exosome, extrinsic component of postsynaptic density membrane, glutamatergic synapse, immunological synapse, myelin sheath abaxonal region, nucleoplasm, plasma membrane, postsynaptic density, presynapse, Scrib-APC-beta-catenin complex |
Calculated MW: | 175kDa |
Observed MW: | 260kDa |
This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 23513 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |