RNF111 Rabbit Polyclonal Antibody (CAB18277)
- SKU:
- CAB18277
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | RNF111 Rabbit Polyclonal Antibody |
SKU: | CAB18277 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human RNF111 (NP_001257459.1). |
Sequence: | ARME SQAT SASI NNSN PSTS EQAS DTAS AVTS SQPS TVSE TSAT LTSN STTG TSIG DDSR RTTS SAVT ETGP PAMP RLPS CCPQ HSPC GGSS QNHH ALGH P |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | ARK; hRNF111; RNF111 |
Positive Sample: | HepG2,SGC-7901,HeLa |
Cellular Localization: | cytoplasm, cytosol, nucleoplasm, nucleus, PML body |
Calculated MW: | 109kDa |
Observed MW: | 120kDa |
The protein encoded by this gene is a nuclear RING-domain containing E3 ubiquitin ligase. This protein interacts with the transforming growth factor (TGF) -beta/NODAL signaling pathway by promoting the ubiquitination and proteosomal degradation of negative regulators, like SMAD proteins, and thereby enhances TGF-beta target-gene transcription. As a modulator of the nodal signaling cascade, this gene plays a critical role in the induction of mesoderm during embryonic development. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.
Purification Method: | Affinity purification |
Gene ID: | 54778 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |