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RFK Antibody (CAB9141)

SKU:
CAB9141
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction
$167 - $503
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Description

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RFK Rabbit Polyclonal Antibody (CAB9141)

The RFK Polyclonal Antibody (CAB9141) is a valuable tool for research involving the RFK protein, which is involved in the regulation of folate metabolism. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the RFK protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in biochemistry and molecular biology.RFK plays a crucial role in the synthesis of tetrahydrofolate, a key molecule in one-carbon metabolism essential for DNA synthesis and cell growth.

Dysregulation of folate metabolism, including RFK, has been linked to various diseases such as cancer, cardiovascular diseases, and neurological disorders. Investigating the function of RFK is important for understanding these disease processes and developing targeted therapies.Overall, the RFK Polyclonal Antibody is a reliable tool for researchers seeking to explore the role of RFK in cellular metabolism and disease pathogenesis. Its specificity and sensitivity make it a valuable asset in the study of folate metabolism and its implications in human health.

Product Name:RFK Rabbit Polyclonal Antibody
SKU:CAB9141
Size:20uL, 100uL
Isotype:IgG
Host Species:Rabbit
Reactivity:Human,Mouse
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-155 of human RFK (NP_060809.3).
Sequence:MRHL PYFC RGQV VRGF GRGS KQLG IPTA NFPE QVVD NLPA DIST GIYY GWAS VGSG DVHK MVVS IGWN PYYK NTKK SMET HIMH TFKE DFYG EILN VAIV GYLR PEKN FDSL ESLI SAIQ GDIE EAKK RLEL PEHL KIKE DNFF QVSK SKIM NGH
Tested Applications:WB ELISA
Recommended Dilution:WB,1:500 - 1:2000
Synonyms:RIFK; RFK
Positive Sample:U-87MG,HeLa,293T,Mouse small intestine,Mouse brain
Conjugate:Unconjugated
Cellular Localization:Cytoplasm.
Calculated MW:18kDa
Observed MW:14kDa

Riboflavin kinase (RFK; EC 2.7.1.26) is an essential enzyme that catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN), an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan et al., 2003 [PubMed 12623014]).

Purification Method:Affinity purification
Gene ID:55312
Storage Buffer:Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Product ImageWestern blot analysis of various lysates using RFK Rabbit pAb (CAB9141) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 90s.

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