Recombinant Human PSMA Protein (Fc Tag) (RPES8337)
- SKU:
- RPES8337
- Size:
- 20μg
- Tag:
- C-Fc
- Reactivity:
- Human
- Expression Host:
- Mammalian
- Accession:
- Q04609
Description
| Product Name: | Recombinant Human PSMA Protein (Fc Tag) |
| SKU: | RPES8337 |
| Size: | 20μg |
| Tag: | C-Fc |
| Reactivity: | Human |
| Expression Host: | Mammalian |
| Accession: | Q04609 |
| Sequence: | Lys44-Ala750 |
| Calculated Molecular Weight: | 102.6 kDa |
| Observed Molecular Weight: | 100-110 kDa |
| Synonyms: | GCP, GIG, Folate hydrolase, Glutamate carboxypeptidase, NAALAD, FGCP, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, mGCP, FOLH1, Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Glutamate carboxypeptidase 2, NAALADase I, N-acetylated alpha-linked acidic dipeptidase 1|cell growth-inhibiting protein 27|folate hydrolase 1|folylpoly-gamma-glutamate carboxypep, GIG27, FGCP, FOLH, GCP2, GCPII, NAALAD1, NAALAdase, PSM, PSMA, mGCP, FOLH1 |
| Endotoxin: | < 1.0 EU/mg of the protein as determined by the LAL method |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
Glutamate carboxypeptidase 2 , also known as Glutamate carboxypeptidase II , Membrane glutamate carboxypeptidase , Prostate-specific membrane antigen , GCPII , PSMA , FOLH1 , and NAALAD1 , is a single-pass type II membrane protein which belongs to thepeptidase M28 family and M28B subfamily. FOLH1 is highly expressed in prostate epithelium. It is detected in urinary bladder , kidney , testis , ovary , fallopian tube , breast , adrenal gland , liver , esophagus , stomach , small intestine , colon , brain (at protein level) , and the capillary endothelium of a variety of tumors. FOLH1 has both folate hydrolase and N-acetylated alpha linked acidic dipeptidase (NAALADase) activity. It has a preference for tri-alpha-glutamate peptides. Genetic variation in FOLH1 may be associated with low folate levels and consequent hyperhomocysteinemia. This condition can result in increased risk of cardiovascular disease , neural tube defects , and cognitive deficits. FOLH1 also shows a promising role in directed imaging and therapy of recurrent or metastatic disease.
| Bio-activity: | Not validated for activity |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
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