Recombinant Human IL-5 Protein (Fc Tag) (RPES8339)
- SKU:
- RPES8339
- Size:
- 20μg
- Tag:
- C-Fc
- Reactivity:
- Human
- Expression Host:
- Mammalian
- Accession:
- P05113
Description
| Product Name: | Recombinant Human IL-5 Protein (Fc Tag) |
| SKU: | RPES8339 |
| Size: | 20μg |
| Tag: | C-Fc |
| Reactivity: | Human |
| Expression Host: | Mammalian |
| Accession: | P05113 |
| Sequence: | Ile20-Ser134 |
| Calculated Molecular Weight: | 37.5 kDa |
| Observed Molecular Weight: | 41 kDa |
| Synonyms: | nterleukin, Interleukin, IL5, EDF, IL-5, TRF, BCDFII, B-cell differentiation factor I, B-cell growth factor I, BCGF-II, Cytotoxic T-lymphocyte inducer, E-CSF, Eosinophil differentiation factor, ESGF, Interleukin-5, nterleukin-5, T-cell replacing factor |
| Endotoxin: | < 1.0 EU/mg of the protein as determined by the LAL method |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
Interleukin 5 (IL-5) is a member of the interleukin family with a length of 115 amino acids. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes) and has been found in a wide variety of body cells. Interleukin 5 or IL-5 is produced by T helper-2 cells and mast cells. It helps to stimulate B cell growth and increase immunoglobulin secretion and is considered a key mediator in eosinophil activation. Interleukin 5 (IL-5) has long been associated with several allergic diseases , including allergic rhinitis and asthma. Growth in the number of circulating , airway tissue , and induced sputum eosinophils have been observed in patients with these diseases. IL-5 also had something with the terminally differentiated granulocyte eosinophils. IL-5 was originally found as an eosinophil colony-stimulating factor. It has been proved to be a major regulator of eosinophil accumulation in tissues and can modulate eosinophil behavior at every stage from maturation to survival.
| Bio-activity: | Not validated for activity |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
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