Recombinant Human IL-18 BPa Protein (Fc Tag) (RPES8352)
- SKU:
- RPES8352
- Size:
- 20μg
- Tag:
- C-Fc
- Reactivity:
- Human
- Expression Host:
- Mammalian
- Accession:
- O95998
Description
| Product Name: | Recombinant Human IL-18 BPa Protein (Fc Tag) |
| SKU: | RPES8352 |
| Size: | 20μg |
| Tag: | C-Fc |
| Reactivity: | Human |
| Expression Host: | Mammalian |
| Accession: | O95998 |
| Sequence: | Thr31-Gly194 |
| Calculated Molecular Weight: | 42.9 kDa |
| Observed Molecular Weight: | 60 kDa |
| Synonyms: | I18BP, IL18 BP, IL18 BPa, IL-18BP, IL18BPa, Interleukin 18 binding protein, Interleukin-18-binding protein, MC51L 53L 54L homolog gene product, Tadekinig alfa, Tadekinig-alfa, Tadekinig-alfa and IL18BP, IL18BP |
| Endotoxin: | < 1.0 EU/mg of the protein as determined by the LAL method |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
Interleukin-18-binding protein (IL-18BP) is a constitutively expressed and secreted protein. IL-18BP is a cytokine receptor that belongs to the interleukin 1 receptor family. This receptor specifically binds interleukin 18 (IL18) and is essential for IL18 mediated signal transduction. IFN-alpha and IL12 are reported to induce the expression of this receptor in NK and T cells. This gene along with four other members of the interleukin 1 receptor family , including IL1R2 , IL1R1 , ILRL2 (IL-1Rrp2) , and IL1RL1 (T1/ST2) , form a gene cluster on chromosome 2q. The adjacently located family members IL18 Receptor 1 (IL18R1) and IL18 receptor accessory protein (IL18RAP) may also be important in the development of asthma and atopy. IL-18 binding protein (IL-18BP) was only moderately elevated , resulting in a high level of biologically active free IL-18 in HPS. A severe IL-18/IL-18BP imbalance results in Th-1 lymphocyte and macrophage activation , which escapes control by NK-cell cytotoxicity and may allow for secondary HPS in patients with underlying diseases.
| Bio-activity: | Not validated for activity |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
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