RASGRP1 Rabbit Polyclonal Antibody (CAB10495)
- SKU:
- CAB10495
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
Product Name: | RASGRP1 Rabbit Polyclonal Antibody |
SKU: | CAB10495 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 598-797 of human RASGRP1 (NP_005730.2). |
Sequence: | PVAP TENN TSVG PVSN LCSL GAKD LLHA PEEG PFTF PNGE AVEH GEES KDRT IMLM GVSS QKIS LRLK RAVA HKAT QTES QPWI GSEG PSGP FVLS SPRK TAQD TLYV LPSP TSPC PSPV LVRK RAFV KWEN KDSL IKSK EELR HLRL PTYQ ELEQ EINT LKAD NDAL KIQL KYAQ KKIE SLQL EKSN HVLA QMEQ GDCS |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200 |
Synonyms: | IMD64; RASGRP; CALDAG-GEFI; CALDAG-GEFII; RASGRP1 |
Positive Sample: | THP-1 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasm, Endoplasmic reticulum membrane, Golgi apparatus membrane, Peripheral membrane protein, cytosol. |
Calculated MW: | 90kDa |
Observed MW: | 90kDa |
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE).
Purification Method: | Affinity purification |
Gene ID: | 10125 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |