Rad50 Rabbit Monoclonal Antibody (CAB3869)
- SKU:
- CAB3869
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Cycle
Frequently bought together:
Description
Product Name: | Rad50 Rabbit Monoclonal Antibody |
SKU: | CAB3869 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1200-1300 of human Rad50 (Q92878). |
Sequence: | RCSA GQKV LASL IIRL ALAE TFCL NCGI IALD EPTT NLDR ENIE SLAH ALVE IIKS RSQQ RNFQ LLVI THDE DFVE LLGR SEYV EKFY RIKK NIDQ CSEI V |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | NBSLD; RAD502; hRad50; Rad50 |
Positive Sample: | HeLa,K-562,U-87MG,Mouse testis,Rat testis |
Conjugate: | Unconjugated |
Cellular Localization: | Chromosome, Nucleus, telomere. |
Calculated MW: | 154kDa |
Observed MW: | 154kDa |
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.
Purification Method: | Affinity purification |
Gene ID: | 10111 |
Clone Number: | ARC0854 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3. |