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QPRT Monoclonal Antibody [PAT24C4AT] (CPAB0233)

SKU:
CPAB0233
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
PAT24C4AT
Applications:
WB
ELISA
FC
€149
Frequently bought together:

Description

system_update_alt Datasheet

QPRT Monoclonal Antibody [PAT24C4AT] (CPAB0233)

The QPRT Polyclonal Antibody (CPAB0233) is a high-quality research tool specifically designed for studying QPRT, an enzyme that plays a key role in the metabolism of tryptophan, an essential amino acid. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications. By binding to the QPRT protein, this antibody enables accurate detection and analysis in a variety of cell types, making it an excellent choice for studies in metabolic research and cancer biology.QPRT is a crucial enzyme involved in the kynurenine pathway, a metabolic pathway that contributes to the regulation of immune responses and maintenance of cellular homeostasis.

Dysregulation of the kynurenine pathway, including alterations in QPRT activity, has been implicated in various diseases, such as cancer, autoimmune disorders, and neurodegenerative conditions. Investigating the function of QPRT using this antibody can provide valuable insights into the underlying mechanisms of these diseases and potentially lead to the development of novel therapeutic strategies targeting tryptophan metabolism.

Product Name:QPRT Antibody
Product Sku:CPAB0233
Size:5μg
Host Species:Mouse
Immunogen:Anti-human QPRT mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human QPRT amino acids 1-297 purified from Ecoli.
Clone:PAT24C4AT.
Reactivity:Human
Applications:Western Blot, ELISA, Flow Cytometry
Purification Method:QPRT antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG2a
Background:QPRT is a key enzyme in the catabolism of quinolinate. QPRT is in between the tryptophannicotinamide adenine dinucleotide (NAD) pathway, resulting in the production of nicotinic acid, carbon dioxide and pyrophosphate. Rise of QPRT levels in the brain is related to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.
Synonyms:Quinolinate phosphoribosyltransferase , QPRTase, QAPRTase.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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