PSMD4 Rabbit Polyclonal Antibody (CAB1061)
- SKU:
- CAB1061
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Monkey
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | PSMD4 Rabbit Polyclonal Antibody |
SKU: | CAB1061 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-377 of human PSMD4 (NP_002801.1). |
Sequence: | MVLE STMV CVDN SEYM RNGD FLPT RLQA QQDA VNIV CHSK TRSN PENN VGLI TLAN DCEV LTTL TPDT GRIL SKLH TVQP KGKI TFCT GIRV AHLA LKHR QGKN HKMR IIAF VGSP VEDN EKDL VKLA KRLK KEKV NVDI INFG EEEV NTEK LTAF VNTL NGKD GTGS HLVT VPPG PSLA DALI SSPI LAGE GGAM LGLG ASDF EFGV DPSA DPEL ALAL RVSM EEQR QRQE EEAR RAAA ASAA EAGI ATTG TEDS DDAL LKMT ISQQ EFGR TGLP DLSS MTEE EQIA YAMQ MSLQ GAEF GQAE SADI DASS AMDT SEPA KEED DYDV MQDP EFLQ SVLE NLPG VDPN NEAI RNAM GSLA SQAT KDGK KDKK EEDK K |
Tested Applications: | WB IF/ICC IP ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 IP,0.5μg-4μg antibody for 200μg-400μg extracts of whole cells |
Synonyms: | AF; ASF; S5A; AF-1; MCB1; Rpn10; pUB-R5; PSMD4 |
Positive Sample: | HUVEC,MCF7 |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, nucleoplasm, nucleus |
Calculated MW: | 41kDa |
Observed MW: | 50kDa |
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21.
Purification Method: | Affinity purification |
Gene ID: | 5710 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |