The PPP6R2 Polyclonal Antibody (CAB8359) is a specialized tool for researchers studying PPP6R2, a regulatory subunit of protein phosphatase 6 that is involved in various cellular processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the PPP6R2 protein, this antibody enables accurate detection and analysis in different cell types, making it an excellent choice for investigations in the fields of cell biology and signal transduction.PPP6R2 is a critical component in the regulation of protein dephosphorylation, playing a vital role in controlling cellular processes such as cell cycle progression and DNA damage response.
Its involvement in these key pathways renders PPP6R2 a compelling target for research focused on understanding mechanisms of disease, particularly in the realms of cancer biology and neurodegenerative disorders. By delving into the functions of PPP6R2, researchers can uncover potential therapeutic strategies that target aberrant signaling pathways and contribute to the development of novel treatments.
Product Name:
PPP6R2 Rabbit Polyclonal Antibody
SKU:
CAB8359
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 640-959 of human PPP6R2 (NP_001229827.1).
The protein encoded by this gene is a regulatory protein for the protein phosphatase-6 catalytic subunit. Together, these proteins act as a significant T-loop phosphatase for Aurora A, an essential mitotic kinase. Loss of function of either the regulatory or catalytic subunit of protein phosphatase-6 interferes with spindle formation and chromosome alignment.
Purification Method:
Affinity purification
Gene ID:
9701
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PPP6R2 antibody (CAB8359) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 10s.
