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PPM1A Monoclonal Antibody [Pp6c7AT] (CPAB0126)

SKU:
CPAB0126
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2b
Clone:
Pp6c7AT
Applications:
WB
ELISA
€149
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Description

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PPM1A Monoclonal Antibody [Pp6c7AT] (CPAB0126)

The PPM1A Polyclonal Antibody (CPAB0126) is a valuable tool for researchers studying PPM1A, a key regulator of cellular processes such as cell cycle progression and apoptosis. This antibody is produced in rabbits and has been validated for use in Western blot applications, demonstrating high reactivity with human samples.PPM1A, also known as protein phosphatase 1A, plays a crucial role in maintaining cellular homeostasis by dephosphorylating target proteins involved in signal transduction pathways. Dysregulation of PPM1A activity has been linked to various diseases, including cancer and neurodegenerative disorders, making it an important target for further investigation.

By using the PPM1A Polyclonal Antibody, researchers can accurately detect and analyze PPM1A protein levels in different cell types, aiding in the understanding of its function and potential therapeutic applications. This antibody is an essential tool for studies in cell biology, cancer research, and drug development focusing on PPM1A and its downstream signaling pathways.

Product Name:PPM1A Antibody
Product Sku:CPAB0126
Size:5μg
Host Species:Mouse
Immunogen:Anti-human PPM1A mAb, is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PPM1A amino acids 1-382 purified from Ecoli.
Clone:Pp6c7AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:PPM1A antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2b
Background:Protein Phosphatase 2C alpha is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding two distinct isoforms have been described. Protein phosphatase 2C(PP2Cα) is a Mn2+- or Mg2+-dependent protein serine/threonine phosphatase that is essential for regulating cellular stress response in eukaryotes.
Synonyms:Protein phosphatase 1A, EC 3.1.3.16, Protein phosphatase 2C isoform alpha, PP2C-alpha, IA, PPM1A, PP2CA, MGC9201.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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