Phospho-eIF2α-S49 Rabbit Polyclonal Antibody (CABP0341)
- SKU:
- CABP0341
- Product Type:
- Antibody
- Applications:
- WB
- IHC
- IF
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Metabolism
Frequently bought together:
Description
Product Name: | Phospho-eIF2α-S49 Rabbit Polyclonal Antibody |
SKU: | CABP0341 |
Size: | 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A phospho specific peptide corresponding to residues surrounding S49 of human EIF2S1 |
Tested Applications: | WB IHC-P |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:100 |
Synonyms: | EIF2; EIF-2; EIF2A; EIF-2A; EIF-2alpha; Phospho-eIF2α-S49 |
Positive Sample: | HeLa |
Conjugate: | Unconjugated |
Cellular Localization: | Cytoplasmic granule. |
Calculated MW: | 36kDa |
Observed MW: | 40kDa |
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).
Purification Method: | Affinity purification |
Gene ID: | 1965 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |