The Anti-ATRIP Antibody (CAB19279) is a crucial tool for researchers studying ATRIP, a critical component of the ATR-ATRIP complex involved in DNA repair and replication. This polyclonal antibody, produced in rabbits, exhibits high specificity and sensitivity towards human ATRIP, making it suitable for Western blot applications. By binding to ATRIP, this antibody allows for the detection and analysis of ATRIP levels in various cell types, facilitating investigations into DNA damage response mechanisms.ATRIP is essential for activating the ATR kinase in response to DNA damage, playing a key role in maintaining genomic stability and preventing the accumulation of mutations that can lead to cancer and other diseases.
Research on ATRIP's function is fundamental to understanding how cells repair DNA damage and maintain genome integrity, offering insights into potential therapeutic strategies for diseases characterized by genomic instability. The Anti-ATRIP Antibody serves as a valuable tool for unraveling the intricate mechanisms of DNA repair and replication pathways, with implications for cancer biology, genetic disorders, and personalized medicine.
Product Name:
ATRIP Rabbit Monoclonal Antibody
SKU:
CAB19279
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human ATRIP (Q8WXE1).
This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
84126
Clone Number:
ARC2460
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using ATRIP antibody (CAB19279) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
