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PE/Cyanine7 Anti-Mouse CD279/PD-1 Antibody [29F.1A12] (AGEL2255)

SKU:
AGEL2255
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2a, κ
Clone:
29F.1A12
Conjugation:
PE/Cyanine7
$215 - $515
Frequently bought together:

Description

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PE/Cyanine7 Anti-Mouse CD279/PD-1 Antibody [29F.1A12]

The PE-Cyanine7 Anti-Mouse CD279 (PD-1) Antibody (29F.1A12) - AG2255 is a powerful tool for studying the PD-1 immune checkpoint pathway in mouse models. This antibody specifically targets the CD279 (PD-1) protein, a key regulator of immune responses, particularly its inhibitory effects on T cell activity. Utilizing cutting-edge PE-Cyanine7 conjugation technology, this antibody provides high sensitivity and specificity in flow cytometry and immunofluorescence applications.PD-1, also known as Programmed Cell Death Protein 1, is a crucial immune checkpoint receptor that plays a significant role in regulating T cell exhaustion and tolerance. The interaction between PD-1 and its ligands is a critical mechanism by which immune responses are modulated, making it a promising target for immunotherapy research.

By blocking or activating the PD-1 pathway, researchers aim to enhance anti-tumor immune responses and treat various immune-related disorders.The PE-Cyanine7 Anti-Mouse CD279 (PD-1) Antibody (29F.1A12) - AG2255 is meticulously validated for its specificity and functionality in mouse samples, ensuring reliable and reproducible results in experimental settings. Its applications in studying immune responses, tumor microenvironments, and immunotherapy make it an indispensable tool for researchers seeking to deepen their understanding of immune regulation and develop innovative therapeutic strategies.

Product Title:PE/Cyanine7 Anti-Mouse CD279/PD-1 Antibody [29F.1A12]
SKU:AGEL2255
Size:50 Tests, 100 Tests, 200 Tests
Clone No:29F.1A12
Synonyms:PD-1; Programmed Death-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine7 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q02242
Gene ID:18566
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

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