PANK2 Rabbit Polyclonal Antibody (CAB18502)
- SKU:
- CAB18502
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
Product Name: | PANK2 Rabbit Polyclonal Antibody |
SKU: | CAB18502 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Mouse |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 300-400 of human PANK2 (NP_705902.2). |
Sequence: | RDKN FSSL HTVF CATG GGAY KFEQ DFLT IGDL QLCK LDEL DCLI KGIL YIDS VGFN GRSQ CYYF ENPA DSEK CQKL PFDL KNPY PLLL VNIG SGVS ILAV Y |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | HSS; HARP; PKAN; NBIA1; C20orf48; PANK2 |
Positive Sample: | Mouse lung |
Cellular Localization: | cytosol, mitochondrial intermembrane space, mitochondrion, nucleus |
Calculated MW: | 63kDa |
Observed MW: | 63kDa |
This gene encodes a protein belonging to the pantothenate kinase family and is the only member of that family to be expressed in mitochondria. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by acyl CoA species. Mutations in this gene are associated with HARP syndrome and pantothenate kinase-associated neurodegeneration (PKAN), formerly Hallervorden-Spatz syndrome. Alternative splicing, involving the use of alternate first exons, results in multiple transcripts encoding different isoforms.
Purification Method: | Affinity purification |
Gene ID: | 80025 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |