PAK1 Rabbit Polyclonal Antibody (CAB2554)
- SKU:
- CAB2554
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
Product Name: | PAK1 Rabbit Polyclonal Antibody |
SKU: | CAB2554 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PAK1 (NP_002567.3). |
Sequence: | MSNN GLDI QDKP PAPP MRNT STMI GAGS KDAG TLNH GSKP LPPN PEEK KKKD RFYR SILP GDKT NKKK EKER PEIS LPSD FEHT IHVG FDAV TGEF TGMP EQWA RLLQ TSNI TKSE QKKN PQAV LDVL EFYN SKKT SNSQ KYMS FTDK SAED YNSS NALN VKAV SETP AVPP VSED EDDD DDDA TPPP VIAP RPEH TKSV YTRS VIEP LPVT PTRD VATS PISP TENN TTPP DALT RNTE |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | IDDMSSD; p65-PAK; PAKalpha; alpha-PAK; PAK1 |
Positive Sample: | SH-SY5Y,HeLa,U2OS,NIH/3T3,C6 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell membrane, Cell projection, Cytoplasm, focal adhesion, invadopodium, ruffle membrane. |
Calculated MW: | 61kDa |
Observed MW: | 68kDa |
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants.
Purification Method: | Affinity purification |
Gene ID: | 5058 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |