The PAK1 Polyclonal Antibody (CAB2554) is a powerful tool for researchers studying PAK1, a key regulator of cell morphology, motility, and invasion. This antibody, generated in rabbits, exhibits high reactivity with human and mouse samples, making it an ideal choice for a wide range of experiments.PAK1 is a serine/threonine protein kinase that plays a crucial role in various cellular processes, including cytoskeletal reorganization and cell proliferation. Dysregulation of PAK1 has been implicated in cancer progression, making it a promising target for anti-cancer therapies.This antibody is validated for use in Western blot applications, enabling researchers to detect and analyze PAK1 protein levels in different cell types and tissues.
By studying the activity of PAK1, researchers can gain valuable insights into its role in cancer development and progression, paving the way for new treatment strategies.Overall, the PAK1 Polyclonal Antibody (CAB2554) is a valuable tool for researchers interested in understanding the role of PAK1 in cancer and other cellular processes. Its high reactivity and specificity make it an essential component of any research project focused on exploring the functions of PAK1 in health and disease.
Product Name:
PAK1 Rabbit Polyclonal Antibody
SKU:
CAB2554
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human PAK1 (NP_002567.3).
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5058
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PAK1 antibody (CAB2554) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
