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OAT Monoclonal Antibody (CPAB0098)

SKU:
CPAB0098
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Applications:
WB
IF
ELISA
€149
Frequently bought together:

Description

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OAT Monoclonal Antibody (CPAB0098)

The OAT Polyclonal Antibody (CPAB0098) is a valuable tool for researchers studying O-Acetyltransferase (OAT), an enzyme involved in the detoxification of xenobiotics and drugs. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the OAT protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in pharmacology and toxicology research.OAT is a key player in the phase II metabolism pathway, contributing to the elimination of potentially harmful substances from the body.

Its role in drug metabolism and detoxification processes makes it a target of interest for researchers investigating drug interactions, drug metabolism, and drug toxicity. Understanding the function and regulation of OAT is essential for advancing our knowledge of how chemicals are processed and eliminated in the body, leading to the development of safer and more effective therapeutic interventions.

Product Name:OAT Antibody
Product Sku:CPAB0098
Size:5μg
Host Species:Mouse
Immunogen:Anti-human OAT mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human OAT amino acids 33-439 purified from Ecoli.
Clone:
Reactivity:Human
Applications:Western Blot, Immunofluorescence, ELISA
Purification Method:OAT antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG1
Background:Ornithine aminotransferase is a key enzyme in the pathway that converts arginine and ornithine into the major excitatory and inhibitory neurotransmitters glutamate and GABA. Ornithine aminotransferase (OAT) is a 49kDa nucleus-encoded protein imported into mitochondria to give the mature 48kDa OAT polypeptide. It is found in humans, animals, insects, plants and microorganisms. The OAT has a sex-differential expression in the mouse kidney. OAT plays central physiological roles in amino acid metabolism. OAT shows a large structural and mechanistic similarity to other enzymes from the subgroup III of aminotransferases that transfer an amino group from a carbon atom which doesn€™t carry a carboxyl function. OAT is vital for nitrogen recycling from arginine but not for the stress-induced proline accumulation. OAT enzyme deficiency causes the autosomal recessive eye disease Gyrate Atrophy.
Synonyms:Ornithine aminotransferase mitochondrial, Ornithine delta-aminotransferase, Ornithine-oxo-acid aminotransferase, OAT, OKT, GACR, HOGA, OATASE, DKFZp781A11155.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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