The NXNL1 Polyclonal Antibody (PAC043900) is a valuable tool for researchers studying the NXNL1 protein, a key player in oxidative stress response and mitochondrial dysfunction. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blot and immunofluorescence.NXNL1, also known as Nexilin, is involved in maintaining mitochondrial function and protecting cells from oxidative damage. Dysregulation of NXNL1 has been linked to a variety of disorders, including neurodegenerative diseases and age-related conditions.
By targeting NXNL1 with this antibody, researchers can explore its role in cellular processes and investigate potential therapeutic interventions for related disorders.With its specificity and reliability, the NXNL1 Polyclonal Antibody is a crucial tool for studies in cell biology, neuroscience, and age-related diseases. By enabling the detection and analysis of NXNL1 expression, this antibody provides valuable insights into the mechanisms underlying oxidative stress and mitochondrial dysfunction, paving the way for new avenues of research and drug development.
Antibody Name:
NXNL1 Antibody (PACO43900)
Antibody SKU:
PACO43900
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human Nucleoredoxin-like protein 1 protein (1-200AA)
Form:
Liquid
Storage Buffer:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method:
Antigen Affinity Purified
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Immunohistochemistry of paraffin-embedded human breast cancer using PACO43900 at dilution of 1:100.
Background:
May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods.
Synonyms:
Nucleoredoxin-like protein 1 (Thioredoxin-like protein 6), NXNL1, TXNL6
UniProt Protein Function:
NXNL1: May play a role in cone cell viability, slowing down cone degeneration, does not seem to play a role in degenerating rods. Belongs to the nucleoredoxin family.Chromosomal Location of Human Ortholog: 19p13.11
UniProt Protein Details:
NCBI Summary:
Retinitis pigmentosa (RP) is a disease that leads to blindness by degeneration of cone photoreceptors. Rods produce factors required for cone viability. The protein encoded by this gene is one of those factors and is similar to a truncated form of thioredoxin. This gene has been proposed to have therapeutic value against RP. [provided by RefSeq, Dec 2015]
