The NFATc1 Polyclonal Antibody (CAB16928) is a valuable tool for researchers studying NFATc1, a key transcription factor involved in regulating immune responses and cell development. This rabbit polyclonal antibody is highly specific and reactive with human samples, making it ideal for use in Western blot applications.NFATc1, also known as nuclear factor of activated T-cells, plays a critical role in immune cell activation and differentiation. It is involved in the regulation of genes responsible for cytokine production and immune cell function.
Studies have shown that dysregulation of NFATc1 activity can lead to autoimmune diseases, inflammatory disorders, and cancer.By using the NFATc1 Polyclonal Antibody, researchers can accurately detect and analyze NFATc1 protein levels in various cell types, providing valuable insights into immune responses and potential therapeutic targets. This antibody is a valuable tool for researchers in immunology, cancer research, and drug development looking to better understand the role of NFATc1 in health and disease.
Product Name:
NFAT2 Rabbit Polyclonal Antibody
SKU:
CAB16928
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 115-298 of NFAT2 (NP_001265598.1).
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.
Purification Method:
Affinity purification
Gene ID:
4772
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using NFAT2 Rabbit pAb (CAB16928) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
