The Neprilysin Polyclonal Antibody (CAB5664) is a valuable tool for researchers studying neprilysin, a key enzyme involved in the degradation of peptides such as amyloid beta, bradykinin, and endothelin. Neprilysin is essential for regulating blood pressure, inflammation, and tissue remodeling, making it an important target for drug development in cardiovascular and neurodegenerative diseases.This polyclonal antibody, generated in rabbits, is highly specific for detecting neprilysin in human samples and is validated for use in Western blotting and immunohistochemistry. It binds to the neprilysin protein, allowing for precise detection and localization in various experimental conditions.
Its versatility makes it ideal for studies in cardiovascular biology, neuroscience, and drug discovery.Understanding the role of neprilysin in peptide degradation and signaling pathways is critical for developing novel therapeutics and diagnostic tools for diseases such as Alzheimer's, heart failure, and hypertension. The Neprilysin Polyclonal Antibody (CAB5664) is a reliable tool for researchers seeking to explore the functions and mechanisms of this important enzyme in health and disease.
Product Name:
CD10/MME Rabbit Polyclonal Antibody
SKU:
CAB5664
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 52-352 of human CD10/MME (NP_000893.2).
Cell membrane, Single-pass type II membrane protein.
Calculated MW:
86kDa
Observed MW:
100kDa
The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin.
Purification Method:
Affinity purification
Gene ID:
4311
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using CD10/MME Rabbit pAb (CAB5664) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
