NEDD8 Polyclonal Antibody (CAB22007)
- SKU:
- CAB22007
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
NEDD8 Polyclonal Antibody (CAB22007)
The NEDD8 Polyclonal Antibody (CAB10008) is a valuable tool for researchers studying neddylation, a post-translational modification process involving the attachment of the small protein NEDD8 to target proteins. This antibody, generated in rabbits, exhibits high specificity for human samples and is optimized for Western blotting applications.NEDD8 modification is involved in various cellular processes, including protein degradation, cell cycle regulation, and DNA repair. Dysregulation of neddylation has been linked to various diseases, such as cancer, neurodegenerative disorders, and viral infections.
Therefore, studying the role of NEDD8 in these contexts is important for understanding disease mechanisms and developing targeted therapies.The NEDD8 Polyclonal Antibody binds specifically to NEDD8-modified proteins, enabling researchers to detect and analyze neddylation events in different cell types and experimental conditions. Its versatility and reliability make it a valuable tool for investigating the complex network of neddylation pathways and their impact on cellular function and disease progression.
| Product Name: | NEDD8 Polyclonal Antibody |
| Product Code: | CAB22007 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | MCF7, C6, 293T, Mouse brain |
| Cellular Location: | cytoplasm, cytosol, extracellular exosome, nucleoplasm, nucleus |
Enables ubiquitin protein ligase binding activity. Acts upstream of or within protein neddylation. Located in cytosol and nucleoplasm. Biomarker of Parkinson's disease and malignant astrocytoma.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-81 of human NEDD8 (NP_006147.1). |
| Sequence: | MLIKV KTLTG KEIEI DIEPT DKVER IKERV EEKEG IPPQQ QRLIY SGKQM NDEKT AADYK ILGGS VLHLV LALRG GGGLR Q |
| Synonyms: | NEDD-8 |
| Calculated MW: | 9kDa |
| Observed MW: | 10kDa |
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