The NDUFA13 Polyclonal Antibody (CAB18071) is a powerful tool for researchers studying NDUFA13, a subunit of the mitochondrial respiratory chain Complex I involved in energy production. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to NDUFA13, this antibody allows for the detection and analysis of this critical protein in various cell types, offering valuable insight into mitochondrial function and cellular metabolism.NDUFA13 is integral to the functioning of Complex I in the electron transport chain, playing a crucial role in ATP synthesis and energy production in cells.
Dysregulation of NDUFA13 has been linked to various metabolic disorders and neurodegenerative diseases, making it a promising therapeutic target for conditions such as Parkinson's disease and Leigh syndrome. By studying NDUFA13 using this antibody, researchers can further our understanding of mitochondrial dysfunction and potentially develop new treatments for these complex diseases.
This gene encodes a subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain. The protein is required for complex I assembly and electron transfer activity. The protein binds the signal transducers and activators of transcription 3 (STAT3) transcription factor, and can function as a tumor suppressor. The human protein purified from mitochondria migrates at approximately 16 kDa. Transcripts originating from an upstream promoter and capable of expressing a protein with a longer N-terminus have been found, but their biological validity has not been determined.
Purification Method:
Affinity purification
Gene ID:
51079
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from wild type (WT) and NDUFA13/GRIM19 knockout (KO) HeLa cells, using [KO Validated] NDUFA13/GRIM19 Rabbit pAb (CAB18071) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
