NCSTN Rabbit Polyclonal Antibody (CAB14505)
- SKU:
- CAB14505
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Description
Product Name: | NCSTN Rabbit Polyclonal Antibody |
SKU: | CAB14505 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 429-669 of human NCSTN (NP_056146.1). |
Sequence: | RFLR ARNI SGVV LADH SGAF HNKY YQSI YDTA ENIN VSYP EWLS PEED LNFV TDTA KALA DVAT VLGR ALYE LAGG TNFS DTVQ ADPQ TVTR LLYG FLIK ANNS WFQS ILRQ DLRS YLGD GPLQ HYIA VSSP TNTT YVVQ YALA NLTG TVVN LTRE QCQD PSKV PSEN KDLY EYSW VQGP LHSN ETDR LPRC VRST ARLA RALS PAFE LSQW SSTE YSTW TESR WKDI RARI FLIA SKEL E |
Tested Applications: | WB IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IF/ICC,1:50 - 1:200 |
Synonyms: | ATAG1874; NCSTN |
Positive Sample: | Mouse brain,Rat brain,Rat spleen |
Conjugate: | Unconjugated |
Cellular Localization: | Melanosome, Membrane, Single-pass type I membrane protein. |
Calculated MW: | 78kDa |
Observed MW: | 110kDa |
This gene encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21. Alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Purification Method: | Affinity purification |
Gene ID: | 23385 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |