The NAB2 Polyclonal Antibody (CAB5827) is a key tool for researchers studying the NAB2 protein, which plays a critical role in gene regulation and tumor suppression. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the NAB2 protein, researchers can effectively detect and analyze its expression in a variety of cell types, making it an essential tool for studies in cancer biology and gene regulation.NAB2, also known as NGFI-A Binding Protein 2, is a transcriptional repressor that interacts with various transcription factors to regulate gene expression.
Its role in tumor suppression makes it a significant target for research in cancer biology and therapeutic development. Understanding the function and regulation of NAB2 is essential for developing novel approaches to treating cancer and other related diseases. The NAB2 Polyclonal Antibody provides researchers with a reliable tool for investigating the role of NAB2 in various cellular processes and disease states.
Product Name:
NAB2 Rabbit Polyclonal Antibody
SKU:
CAB5827
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human NAB2 (NP_005958.1).
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Purification Method:
Affinity purification
Gene ID:
4665
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using NAB2 antibody (CAB5827) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
