MRPL3 Antibody (PACO22423)
- SKU:
- PACO22423
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
MRPL3 Antibody (PACO22423)
The MRPL3 Polyclonal Antibody (PAC022423) is a specialized tool for studying MRPL3, a mitochondrial ribosomal protein with implications in cellular energy production. This antibody, developed using rabbits, exhibits high specificity for human samples and has been validated for use in Western blot applications. By recognizing and binding to the MRPL3 protein, this antibody enables precise detection and analysis in various cell types, making it well-suited for investigations in the fields of mitochondrial biology and metabolic research.MRPL3 is a key component of the mitochondrial ribosome, essential for the translation of mitochondrial DNA-encoded proteins involved in oxidative phosphorylation.
Dysregulation of MRPL3 has been linked to mitochondrial dysfunction and cellular energy deficits, making it a target of interest in studies related to metabolic disorders, neurodegenerative diseases, and cancer. Understanding the role of MRPL3 in cellular energy production and metabolism is crucial for uncovering potential therapeutic strategies for diseases associated with mitochondrial dysfunction.
| Antibody Name: | MRPL3 Antibody (PACO22423) |
| Antibody SKU: | PACO22423 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from Internal of human MRPL3. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from K562 cells, using MRPL3 antibody. |
| Background: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q. |
| Synonyms: | 39S ribosomal protein L3; mitochondrial; L3mt; mitochondrial 60S ribosomal protein L3; mitochondrial ribosomal protein L3 |
| UniProt Protein Function: | MRPL3: Defects in MRPL3 are the cause of combined oxidative phosphorylation deficiency type 9 (COXPD9). A mitochondrial disease characterized by failure to thrive, poor feeding, hypertrophic cardiomyopathy, hepatomegaly, and psychomotor retardation. Death in infancy has been observed in some cases. Belongs to the ribosomal protein L3P family.Protein type: Mitochondrial; Ribosomal; Translation; RNA-bindingChromosomal Location of Human Ortholog: 3q21-q23Cellular Component: mitochondrial inner membrane; mitochondrial large ribosomal subunitMolecular Function: structural constituent of ribosome; RNA bindingBiological Process: mitochondrial translation; translation; organelle organization and biogenesisDisease: Combined Oxidative Phosphorylation Deficiency 9 |
| UniProt Protein Details: | |
| NCBI Summary: | Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L3P ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 13q. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P09001 |
| NCBI GenInfo Identifier: | 6005862 |
| NCBI Gene ID: | 11222 |
| NCBI Accession: | NP_009139.1 |
| UniProt Secondary Accession: | P09001,Q6IBT2 |
| UniProt Related Accession: | P09001 |
| Molecular Weight: | 38,633 Da |
| NCBI Full Name: | 39S ribosomal protein L3, mitochondrial |
| NCBI Synonym Full Names: | mitochondrial ribosomal protein L3 |
| NCBI Official Symbol: | MRPL3Â Â |
| NCBI Official Synonym Symbols: | MRL3; RPML3; COXPD9Â Â |
| NCBI Protein Information: | 39S ribosomal protein L3, mitochondrial; L3mt; MRP-L3; mitochondrial 60S ribosomal protein L3 |
| UniProt Protein Name: | 39S ribosomal protein L3, mitochondrial |
| UniProt Synonym Protein Names: | |
| Protein Family: | 39S ribosomal protein |
| UniProt Gene Name: | MRPL3Â Â |
| UniProt Entry Name: | RM03_HUMAN |
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