The MRPL14 Polyclonal Antibody (PACo01091) is an essential tool for researchers studying MRPL14, a mitochondrial ribosomal protein involved in the translation process within mitochondria. This antibody is produced in rabbits and has been rigorously validated for use in Western blot applications, providing accurate and reliable results.MRPL14 plays a crucial role in mitochondrial function and has been implicated in various diseases, including cancer and metabolic disorders. By targeting MRPL14 with this antibody, researchers can gain insight into its expression levels, localization, and role in mitochondrial protein synthesis.
This information is invaluable for understanding the molecular mechanisms underlying these diseases and identifying potential therapeutic targets.Overall, the MRPL14 Polyclonal Antibody (PACo01091) is a valuable tool for researchers in the fields of molecular biology, biochemistry, and medicine who are interested in unraveling the complex functions of MRPL14 and its implications in human health and disease.
Antibody Name:
MRPL14 Antibody
Antibody SKU:
PACO01091
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB, IHC
Recommended Dilutions:
WB:1:500-1:2000, IHC:1:100-1:300
Species Reactivity:
Human, Mouse, Rat
Immunogen:
synthesized peptide derived from the C-terminal region of human MRP-L14.
Form:
Liquid
Storage Buffer:
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Synonyms:
MRPL14; MRPL32; RPML32; 39S ribosomal protein L14; mitochondrial; L14mt; MRP-L14; 39S ribosomal protein L32, mitochondrial; L32mt; MRP-L32
UniProt Protein Function:
MRPL14: Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation (Probable). Belongs to the ribosomal protein L14P family.Protein type: TranslationChromosomal Location of Human Ortholog: 6p21.3Cellular Component: mitochondrial inner membrane; ribosomeMolecular Function: structural constituent of ribosomeBiological Process: mitochondrial translation; organelle organization and biogenesis
UniProt Protein Details:
NCBI Summary:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found at 17p13.3. [provided by RefSeq, Jul 2008]
