The Mouse CD71 Monoclonal Antibody (AF488 Conjugated) R17-217-1-3 (TIB-219) (AGEL1203) offered by AssayGenie is a highly specific antibody designed for research applications involving the CD71 antigen, also known as transferrin receptor. This antibody, conjugated with AF488 for fluorescent detection, is derived from mouse hybridoma clone R17-217-1-3 (TIB-219) and is ideal for use in flow cytometry and fluorescence microscopy.The CD71 antigen is a critical cell surface marker involved in iron metabolism and cell proliferation, making it a key target for studies related to cell biology, immunology, and cancer research. By targeting the CD71 antigen, researchers can investigate processes such as cellular iron uptake, transferrin binding, and cell cycle regulation.
The AF488 conjugation of this antibody allows for visualizing and quantifying the expression of CD71 in various cell types, providing valuable insights into cellular processes and disease mechanisms.With its high specificity and sensitivity, the Mouse CD71 Monoclonal Antibody (AF488 Conjugated) R17-217-1-3 (TIB-219) (AGEL1203) from AssayGenie is a valuable tool for researchers seeking to elucidate the role of the CD71 antigen in physiological and pathological conditions. Whether studying iron homeostasis, cell growth regulation, or cancer progression, this antibody enables precise detection and analysis of CD71 expression, advancing scientific understanding in diverse fields of research.
Transferrin receptor protein 1;Tfrc;TR;TfR;TfR1;Trfr;CD71;
Host Species:
Rat
Reactivity:
Mouse
Application:
FCM
Isotype:
Rat IgG2a, κ
Isotype Control:
Genie Fluor 488 Rat IgG2a, κ Isotype Control[2A3]
Form:
Liquid
Conjugation:
Genie Fluor488
Recommended Use:
Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:
Swissprot:
Q62351
Gene ID:
22042
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD71 is a 95 kD type II heterodimeric transmembrane glycoprotein that is also known as T9 and transferrin receptor. CD71 is expressed on proliferating cells, reticulocytes, and erythroid precursors. Its expression is very low on resting leukocytes. CD71 plays a role in the control of cellular proliferation by facilitating the uptake of iron via ferrotransferrin binding and the recycling of apotransferrin to the cell surface.