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Mouse CD25 monoclonal antibody (APC) (AGIM0553)

SKU:
AGIM0553
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Host Species:
Rat
Isotype:
IgG1
Clone:
PC61.5.3
Conjugation:
APC
Applications:
FC
$215
Frequently bought together:

Description

system_update_altDatasheet
Product Name:Mouse CD25 monoclonal antibody (APC)
Product Code:AGIM0553
Size:100 µL
Reactivity:Mouse
Clone:PC61.5.3
Applications:Flow Cytometry
Conjugate:APC
Isotype:IgG1
Host Species:Rat
Storage:Store at 4°C. Avoid prolonged exposure to light.
Uniprot:P01590
Background:CD25 (IL2Ralpha, Tac) is a ligand-binding alpha subunit of interleukin 2 receptor (IL2R). Together with beta and gamma subunit CD25 constitutes the high affinity IL2R, whereas CD25 alone serves as the low affinity IL2R. CD25 expression rapidly increases upon T cell activation. The 55 kDa CD25 molecule is enzymatically cleaved and shed from the cell surface as a soluble 45 kDa s-Tac, whose concentration in serum can be used as a marker of T cell activation. Expression of CD25 indicates the neoplastic phenotype of mast cells. CD25+ CD4+ FoxP3+ regulatory cells (Treg cells) play a crucial role in the control of organ-specific autoimmune diseases.
UniProt Protein Function:IL2RA: Receptor for interleukin-2. Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.
UniProt Protein Details:

Protein type:Membrane protein, integral

Cellular Component: cell surface; membrane; integral to membrane; external side of plasma membrane

Molecular Function:protein binding; interleukin-2 receptor activity; drug binding; interleukin-2 binding

Biological Process: Notch signaling pathway; regulation of T cell homeostatic proliferation; negative regulation of immune response; negative regulation of defense response to virus; positive regulation of activated T cell proliferation; negative regulation of lymphocyte proliferation; inflammatory response to antigenic stimulus; negative regulation of T cell proliferation; positive regulation of T cell differentiation; negative regulation of inflammatory response; T cell homeostasis; positive regulation of T cell proliferation; immune response; activated T cell apoptosis

UniProt Code:P01590
NCBI GenInfo Identifier:124318
NCBI Gene ID:16184
NCBI Accession:P01590.1
UniProt Related Accession:P01590
Molecular Weight:
NCBI Full Name:Interleukin-2 receptor subunit alpha
NCBI Synonym Full Names:interleukin 2 receptor, alpha chain
NCBI Official Symbol:Il2ra  
NCBI Official Synonym Symbols:CD25; Il2r; Ly-43  
NCBI Protein Information:interleukin-2 receptor subunit alpha
UniProt Protein Name:Interleukin-2 receptor subunit alpha
UniProt Synonym Protein Names:p55; CD_antigen: CD25
UniProt Gene Name:Il2ra  
UniProt Entry Name:IL2RA_MOUSE

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