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Anti-METTL4 Antibody (CAB9294)

SKU:
CAB9294
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology
€139 - €419
Frequently bought together:

Description

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Anti-METTL4 Antibody (CAB9294)

The METTL4 Polyclonal Antibody (CAB9294) is a valuable tool for researchers studying METTL4, a protein involved in epigenetic regulation and RNA methylation. This antibody, produced in rabbits, is highly specific for METTL4 in human samples and is suitable for use in Western blotting and other applications. By targeting the METTL4 protein, this antibody allows for the detection and analysis of METTL4 expression in various cell types, making it essential for studies in the fields of epigenetics and RNA biology.METTL4 is a methyltransferase enzyme that plays a critical role in the methylation of RNA molecules, impacting various cellular processes including mRNA stability and translation efficiency.

Dysregulation of METTL4 has been linked to several diseases, including cancer and neurological disorders, highlighting its importance as a potential therapeutic target. By utilizing the METTL4 Polyclonal Antibody, researchers can further explore the functions and mechanisms of METTL4, ultimately leading to a better understanding of its role in disease pathology and the development of targeted interventions.

Antibody Name:Anti-METTL4 Antibody
Antibody SKU:CAB9294
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human METTL4 (NP_073751.3).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, 293T, HeLa, MCF7, Mouse brain, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human METTL4 (NP_073751.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSVV HQLS AGWL LDHL SFIN KINY QLHQ HHEP CCRK KEFT TSVH FESL QMDS VSSS GVCA AFIA SDSS TKPE NDDG GNYE MFTR KFVF RPEL FDVT KPYI TPAV HKEC QQSN EKED LMNG VKKE ISIS IIGK KRKR CVVF NQGE LDAM EYHT KIRE LILD GSLQ LIQE GLKS GFLY PLFE KQDK GSKP IT
Gene ID:64863
Uniprot:Q8N3J2
Cellular Location:
Calculated MW:54kDa
Observed MW:54kDa
Synonyms:METTL4, HsT661
Background:
UniProt Protein Function:METTL4: Probable methyltransferase. Belongs to the MT-A70-like family.
UniProt Protein Details:

Protein type:EC 2.1.1.-; Methyltransferase

Chromosomal Location of Human Ortholog: 18p11.32

Molecular Function:methyltransferase activity; nucleic acid binding

Biological Process: methylation; nucleobase, nucleoside, nucleotide and nucleic acid metabolic process

UniProt Code:Q8N3J2
NCBI GenInfo Identifier:145275206
NCBI Gene ID:64863
NCBI Accession:NP_073751.3
UniProt Secondary Accession:Q8N3J2,Q2TAA7, Q9H5U9, B2RNA1,
UniProt Related Accession:Q8N3J2
Molecular Weight:
NCBI Full Name:methyltransferase-like protein 4 isoform 1
NCBI Synonym Full Names:methyltransferase like 4
NCBI Official Symbol:METTL4  
NCBI Official Synonym Symbols:HsT661  
NCBI Protein Information:methyltransferase-like protein 4
UniProt Protein Name:Methyltransferase-like protein 4
Protein Family:Methyltransferase-like protein
UniProt Gene Name:METTL4  
UniProt Entry Name:METL4_HUMAN
Anti-METTL4 Polyclonal Antibody (CAB9294)Western blot analysis of extracts of various cell lines, using METTL4 antibody (CAB9294) at 1:2000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.

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