MDFIC Antibody (PACO20000)
- SKU:
- PACO20000
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
MDFIC Antibody (PACO20000)
The MDFIC Polyclonal Antibody (PAC020000) is a valuable tool for researchers studying MDFIC, a protein involved in cell differentiation and tumorigenesis. This antibody, produced in rabbits, has high specificity for human samples and is validated for use in Western blot applications. By binding to the MDFIC protein, this antibody enables precise detection and analysis in various cell types, making it an ideal choice for studies in cancer research and cell biology.MDFIC, also known as MyoD family inhibitor domain-containing protein, plays a crucial role in regulating cell growth and differentiation, making it a key player in cancer development and progression.
Understanding the function of MDFIC is essential for uncovering its potential as a therapeutic target in cancer treatment. By studying MDFIC expression and activity, researchers can gain insights into tumor growth mechanisms and potentially identify new strategies for cancer therapy.
| Antibody Name: | MDFIC Antibody (PACO20000) |
| Antibody SKU: | PACO20000 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:1000-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human MDFIC |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20000(MDFIC Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using PACO20000(MDFIC Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants. |
| Synonyms: | MyoD family inhibitor domain containing |
| UniProt Protein Function: | MDFIC: Acts as a transcriptional activator or repressor. Inhibits the transcriptional activation of Zic family proteins ZIC1, ZIC2 and ZIC3. Retains nuclear Zic proteins ZIC1, ZIC2 and ZIC3 in the cytoplasm. Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin- beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways. Belongs to the MDFI family. 2 isoforms of the human protein are produced by alternative initiation.Protein type: NucleolusChromosomal Location of Human Ortholog: 7q31.1-q31.2Cellular Component: Golgi apparatus; nucleoplasmMolecular Function: cyclin binding; protein binding; Tat protein binding; transcription factor bindingBiological Process: activation of JNK activity; negative regulation of protein import into nucleus; negative regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; positive regulation of viral transcription; regulation of Wnt receptor signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] |
| UniProt Code: | Q9P1T7 |
| NCBI GenInfo Identifier: | 257051035 |
| NCBI Gene ID: | 29969 |
| NCBI Accession: | Q9P1T7.2 |
| UniProt Secondary Accession: | Q9P1T7,Q9P1T6 |
| UniProt Related Accession: | Q9P1T7 |
| Molecular Weight: | 37,042 Da |
| NCBI Full Name: | MyoD family inhibitor domain-containing protein |
| NCBI Synonym Full Names: | MyoD family inhibitor domain containing |
| NCBI Official Symbol: | MDFICÂ Â |
| NCBI Official Synonym Symbols: | HICÂ Â |
| NCBI Protein Information: | myoD family inhibitor domain-containing protein |
| UniProt Protein Name: | MyoD family inhibitor domain-containing protein |
| UniProt Synonym Protein Names: | I-mfa domain-containing protein; hIC |
| Protein Family: | |
| UniProt Gene Name: | MDFICÂ Â |
| UniProt Entry Name: | MDFIC_HUMAN |
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